Remigiusz Adam Serwa

TIAR-dependent coordination of alternative splicing and lipid peroxidation is required for CML cell resistance to imatinib in the bone marrow stroma

A host ATPase essential for rhinovirus replication is an antiviral target with a high barrier to resistance

This study identifies RUVBL1/2 as a host ATPase essential for rhinovirus replication and shows that its inhibition effectively blocks viral replication without resistance development.

Lysosomal accumulation of Masitinib alters autophagy via pH-dependent trapping.

This study shows that masitinib accumulates in lysosomes via pH-dependent trapping, disrupting autophagy by impairing lysosomal acidification.

Loss of Brg1 promotes seizure development via GABAergic system disruption

This study shows that reduced Brg1 function in zebrafish leads to seizure-like behavior through disruption of the GABAergic system and increased neuronal activity.

A dosage-sensitive ALLO-1 network coordinates mitochondrial quality control to enable functional recovery of structurally compromised muscle

The paper identifies an ALLO-1 network that coordinates mitochondrial quality control in C. elegans muscle, enabling functional recovery despite structural damage.

Temporal and protein-specific S-palmitoylation supports synaptic and neural network plasticity

This study shows that S-palmitoylation differentially affects synaptic plasticity and neuronal spiking timing, targeting specific proteins in excitatory synapses.

Mechanistic Insights into TYSM Protein Regulation by mTORC2 in Response to Chemotherapy.

The paper shows that TYMS protein levels change in a biphasic manner after 5-FU treatment, driven by translation rather than transcription, and identifies SIN1 as a key regulator.

Targeted Protein Degradation in Escherichia coli - depletion of the essential GroEL using CLIPPERs

This paper introduces a method for targeted protein degradation in bacteria using degrader peptides that exploit the ClpXP protease, demonstrating its effectiveness on the essential GroEL protein.

Sterility-Independent Enhancement of Proteasome Function via Floxuridine-Triggered Detoxification in C. elegans

This study shows that floxuridine enhances proteasome function in C. elegans, improves cold survival, and activates a detoxification pathway independent of SKN-1 and the germline.

OMA1 protease eliminates arrested protein import intermediates upon depolarization of the inner mitochondrial membrane.

The paper identifies OMA1 protease as a key factor in resolving arrested protein import intermediates in human cells through mitochondrial membrane depolarization.