Isaac Rodríguez-Rovira

Integrated luminescence and phenotypic profiling for drug discovery in a zebrafish model of Marfan syndrome

This study uses a zebrafish model of Marfan syndrome to identify potential therapies through a high-throughput drug screen and luminescence-based phenotyping.

Differential contribution of elastin and fibrillin-1 to the cardiovascular phenotype of a double heterozygous Marfan and Williams-Beuren syndrome mouse model

This study examines a double heterozygous mouse model of Marfan and Williams-Beuren syndromes, showing combined vascular and cardiac phenotypes related to elastin and fibrillin-1.

Impact of the maternal environment on cardiovascular features of the offspring in a mouse model of Marfan syndrome

This study investigates how the maternal environment affects cardiovascular traits in MFS offspring using a mouse model, finding maternal inheritance leads to earlier aortic enlargement and persistent cardiac issues.

Allopurinol improves cardiovascular phenotypes of a mouse model for Williams-Beuren syndrome reducing redox stress

This study evaluates the effects of Allopurinol and Losartan on cardiovascular phenotypes in a mouse model of Williams-Beuren syndrome, finding that Allopurinol reduces blood pressure and improves cardiac pathology.

HYPERURICAEMIA DOES NOT INTERFERE WITH AORTOPATHY IN A MURINE MODEL OF MARFAN SYNDROME

This study investigates whether hyperuricaemia affects aortopathy and cardiopathy in a murine model of Marfan syndrome, finding no significant interference.

Curcumin combined with verapamil improve cardiovascular phenotype of a Williams-Beuren Syndrome mice model reducing oxidative stress

The paper investigates the effect of curcumin and verapamil on cardiovascular phenotype in a Williams-Beuren Syndrome mice model, finding reduced oxidative stress and improved cardiovascular outcomes.