Structural characterization and inhibition of the interaction between ch-TOG and TACC3
James Shelford, Selena G. Burgess, Elena V. Rostkova, Mark W. Richards, Gabrielle Larocque, Josephina Sampson, Christian Tiede, Alistair J. Fielding, Tina Daviter, Darren Charles Tomlinson, Antonio N. Calabrese, Mark Pfuhl, Richard W. Bayliss, Stephen Royle
This study determines the structure of the ch-TOG-TACC3 interaction and shows that inhibiting it causes pericentriolar material fragmentation and delayed mitosis.
The Journal of Cell Biology · Feb 20, 2025Peer-reviewedCell Biology