Darren Charles Tomlinson

This paper identifies small molecules targeting the Tenascin C fibrinogen-like globe domain to reduce fibrosis in systemic sclerosis by inhibiting Toll-like receptor 4 signaling.

This study determines the structure of the ch-TOG-TACC3 interaction and shows that inhibiting it causes pericentriolar material fragmentation and delayed mitosis.

This paper identifies two RAS-binding Affimer proteins that inhibit RAS function and reveal a novel druggable SII/3 pocket.