Antonio N. Calabrese

This study benchmarks sub-50 nm quartz nanopipette emitters for native electrospray ionization mass spectrometry across multiple platforms and protein sizes, showing improved signal-to-noise and reduced adduction.

The paper investigates how the BRCA1-A complex recognizes and cleaves K63-linked polyubiquitin chains, revealing structural and functional mechanisms involved in DNA damage response.

This study determines the structure of herpes simplex virus 2 glycoprotein C interacting with C3b, revealing a unique mechanism to modulate the complement cascade.

The paper identifies the DNA binding domain of TFIIIC5 as a key interaction site for N-myc and elucidates the molecular mechanism of their interaction using structural and biophysical methods.

This study uses nanopipette electrospray ionisation ion mobility mass spectrometry to investigate how buffer conditions affect α-synuclein conformational dynamics.

This study shows that phosphorylation enables distinct nucleation mechanisms for NSP5 condensate formation in rotaviruses, depending on strain-specific LLPS propensity.

The paper identifies first-in-class inhibitors (BLUEs) that selectively inhibit BRISC complex activity by stabilizing an autoinhibited dimer, reducing interferon-stimulated gene expression.

This study determines the structure of the ch-TOG-TACC3 interaction and shows that inhibiting it causes pericentriolar material fragmentation and delayed mitosis.

This study develops and characterizes oNBA-based crosslinkers for structural proteomics, showing high labelling efficiency and crosslinking yields with optimized photolysis conditions.

The paper identifies 490 interactors of RTK PRM regions using affinity purification mass spectrometry, revealing overrepresented metabolic and migratory functions in cancer cells.

The paper isolates a bovine ultralong CDRH3 antibody that targets a conserved, cryptic epitope on SARS-CoV and SARS-CoV-2, demonstrating its neutralizing activity through specific epitope recognition.