Kim M. Stegmann

This study shows that combining Nirmatrelvir with GRP78 inhibitors strongly reduces SARS-CoV-2 replication in vitro and in a hamster model.

This paper shows that combining N4-hydroxycytidine with CTP synthetase inhibitors strongly reduces SARS-CoV-2 replication in cell culture and animal models.

This paper shows that combining N4-hydroxycytidine and DHODH inhibitors strongly reduces SARS-CoV-2 replication in cell cultures.

This paper shows that methotrexate inhibits SARS-CoV-2 replication in cell cultures and synergizes with remdesivir, suggesting potential for repurposing MTX in treating COVID-19.