Matthias Dobbelstein

The paper tests cell-permeable 5-fluorodeoxyuridine triphosphate derivatives against Plasmodium falciparum and finds they inhibit parasite proliferation while being selectively rescued by thymidine in human cells.

This study shows that combining Nirmatrelvir with GRP78 inhibitors strongly reduces SARS-CoV-2 replication in vitro and in a hamster model.

This study shows that RSL3 and Pyrimethamine synergistically inhibit Plasmodium falciparum growth, with a mechanism distinct from canonical ferroptosis.

This paper shows that combining N4-hydroxycytidine with CTP synthetase inhibitors strongly reduces SARS-CoV-2 replication in cell culture and animal models.

This study shows that combining KRAS and CDK4/6 inhibitors synergistically suppresses pancreatic cancer cells and organoids with KRAS mutations, with durable effects even after drug washout.

This paper shows that DHODH inhibitors enhance the antiviral effect of 4'-FlU against multiple RNA viruses, including influenza, SARS-CoV-2, and Ebola virus.

This paper shows that combining N4-hydroxycytidine and DHODH inhibitors strongly reduces SARS-CoV-2 replication in cell cultures.

This paper shows that methotrexate inhibits SARS-CoV-2 replication in cell cultures and synergizes with remdesivir, suggesting potential for repurposing MTX in treating COVID-19.