Author

Josep Calafell-Segura

Josep Carreras Leukaemia Research InstituteORCID 0000-0002-0173-8221Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Assay:DNA methylation· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Esteban BallestariD· 3 shared Javier Rodríguez‐UbrevaiD· 3 shared Aleksey LazarenkoviD· 1 shared Anna Guiomar Ferreté-BonastreiD· 1 shared Anna V. López-RubioiD· 1 shared Ariadna LagunaiD· 1 shared Bárbara LealiD· 1 shared Celia Lourdes Calvillo· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersGenomics

Esteban BallestarORCID

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3 papers

Recent·Most cited

GenomicsScience AdvancesPeer-reviewedJul 16, 2025

Modulating immune cell fate and inflammation through CRISPR-mediated DNA methylation editing

Gemma Valcárcel, Anna V. López-Rubio, Aleksey Lazarenkov…·José Luis Sardina

The paper establishes a cause-and-effect relationship between DNA methylation at the IL1RN promoter and gene expression, showing its impact on myeloid cell fate and inflammatory response.

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humanDNA methylation

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NeuroscienceNature CommunicationsPeer-reviewedJan 16, 2025

The Human Microglia Atlas (HuMicA) Unravels Changes in Homeostatic and Disease-Associated Microglia Subsets across Neurodegenerative Conditions

Ricardo Martins-Ferreira, Josep Calafell-Segura, Bárbara Leal…·Esteban Ballestar

The paper constructs a human microglia transcriptomic atlas, identifying 11 subpopulations across neurodegenerative conditions and revealing changes in homeostatic and disease-associated microglia subsets.

123 citationstop 1%

humansnRNA-seq

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ImmunologyAnnals of the Rheumatic DiseasesPeer-reviewedFeb 27, 2024

Divergent Epigenetic and Transcriptomic Reprogramming of Monocyte Subpopulations in Systemic Lupus Erythematosus

Anna Guiomar Ferreté-Bonastre, Mónica Martínez‐Gallo, Octavio Morante-Palacios…·Esteban Ballestar

This study identifies epigenetic and transcriptomic changes in SLE monocyte subsets, linking them to disease activity and function.

35 citationstop 1%

humanbulk RNA-seq

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