Ariadna Laguna

Alpha-synuclein and neuromelanin converge to promote Parkinsons disease pathology

This study identifies a bidirectional pathogenic relationship between alpha-synuclein and neuromelanin in Parkinson's disease, showing they promote each other's accumulation and neuronal loss.

Age-dependent brain pigmentation drives early neuroinflammatory molecular signatures linked to neurodegeneration

This study identifies age-dependent neuroinflammatory changes in NM-containing neurons linked to neurodegeneration, with GPNMB as a conserved protective factor in Parkinson's disease.

The Human Microglia Atlas (HuMicA) Unravels Changes in Homeostatic and Disease-Associated Microglia Subsets across Neurodegenerative Conditions

The paper constructs a human microglia transcriptomic atlas, identifying 11 subpopulations across neurodegenerative conditions and revealing changes in homeostatic and disease-associated microglia subsets.

Modelling human neuronal catecholaminergic pigmentation in rodents recapitulates age-related multisystem neurodegenerative deficits

This paper creates a transgenic mouse model that mimics human neuromelanin accumulation in catecholaminergic neurons, leading to age-related neurodegenerative deficits.

Non-ablative disease-modifying effects of magnetic resonance-guided focused ultrasound in neuromelanin-producing parkinsonian rodents

Transcranial focused ultrasound reduces neuromelanin accumulation and provides therapeutic benefits in parkinsonian rats without additional interventions.

In vivo reduction of age-dependent neuromelanin accumulation mitigates features of Parkinson's disease

This study reduces age-related neuromelanin accumulation in a humanized rodent model, mitigating Parkinson's disease features by preserving dopamine homeostasis and neuronal integrity.