Esteban Ballestar

The paper establishes a cause-and-effect relationship between DNA methylation at the IL1RN promoter and gene expression, showing its impact on myeloid cell fate and inflammatory response.

The paper constructs a human microglia transcriptomic atlas, identifying 11 subpopulations across neurodegenerative conditions and revealing changes in homeostatic and disease-associated microglia subsets.

This study identifies epigenetic differences in SLE linked to genetics, transcription, and serology, revealing novel drug targets and pathways.

The paper examines DNA methylation and transcriptomic changes in monocytes from severe COVID-19 patients, identifying epigenetic and transcriptional reprogramming linked to myeloid differentiation and inflammatory cytokines.

This study identifies novel genetic drivers in Sjogrens Syndrome through an integrative multi-omics approach, revealing epigenetic signatures and regulatory variants associated with the disease.

The paper identifies sampling artifacts in single-cell genomics and proposes solutions to mitigate them in cohort studies.

The paper presents STATegra, a multi-omics dataset of mouse B-cell differentiation combining 10 omics technologies to study dynamic cellular processes.