Chenxi Wang

This study identifies m1A58 as a conformational checkpoint that links tRNAiMet maturation to translation initiation and stress responses by stabilizing tRNA structure and processing.

This paper introduces a Bayesian method to optimize metamodels for complex biological systems, showing improved accuracy in modeling beta-cell function in T2D.

Si-C reconstructs biologically valid super-resolution 3D genome structures from sparse single-cell Hi-C data, revealing cell-to-cell variation and hyperfine chromatin features.