Haydar Witwit

This study identifies Sirt-1 as a host factor required for optimal LCMV multiplication and suggests repurposing Sirt-1 inhibitors as antivirals.

This study identifies sphingolipid metabolism as a target for antiviral strategies against mammarenaviruses by showing that inhibiting nSMase2 reduces viral production.

This paper shows halofuginone inhibits mammarenavirus replication by targeting prolyl-tRNA synthetase, leading to translation inhibition and reduced viral budding.

The paper screens a compound library to identify anti-mammarenavirus agents, finding CRM1/XPO1 inhibitors as promising therapeutic targets.

This study shows NMT inhibitors remain effective against viruses like HSV-1 even when JAK inhibitors like ruxolitinib are present, suggesting their use in treating immunosuppression-related viral infections.

The paper investigates the role of Z protein myristoylation and oligomerization in inhibiting vRNP activity, finding that inhibition is dose-dependent and monomeric-dependent, not requiring myristoylation.

This study shows that NMT inhibition reduces mammarenavirus replication by impairing Z protein budding and GP2 fusion activity.