Author

Karolina Mitusińska

Silesian University of TechnologyORCID 0000-0002-0183-0845Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:protein structure· 3 Approach:statistical model· 3 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Organism:virus· 1

Frequent Co-Authors

Artur GóraiD· 3 shared Agata RaczyńskaiD· 2 shared Aleksandra SamoliD· 2 shared Maria BzówkaiD· 2 shared Alessandra MagistratoiD· 1 shared Angela PariseiD· 1 shared Aravind Selvaram ThirunavukarasuiD· 1 shared Gamze TanriveriD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBioinformatics

Artur GóraORCID

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4 papers

Recent·Most cited

Glutamine Tautomerization Drives RhoGAP-Aided GTP Hydrolysis in Small Rho GTPases

Angela Parise, Riccardo Rozza, Karolina Mitusińska, Jana Aupič, Alessandra Magistrato

The paper resolves the mechanism of GTP hydrolysis in the RhoGAP-RhoA complex, revealing a tautomerization-driven process involving Gln63.

Journal of the American Chemical Society · Jun 15, 2026Peer-reviewedBiophysics

Water migration through enzyme tunnels is sensitive to choice of explicit water model

Aravind Selvaram Thirunavukarasu, Katarzyna Szleper, Gamze Tanriver, Igor Marchlewski, Karolina Mitusińska, Artur Góra, Jan Brezovský

This study investigates how different water models affect water molecule migration through enzyme tunnels, finding that TIP3P allows faster and greater transport compared to OPC and TIP4P-Ew.

Journal of Chemical Information and Modeling · Dec 16, 2024Peer-reviewedBioinformatics

Evolution of tunnels in alpha/beta-hydrolase fold proteins - what can we learn from studying epoxide hydrolases?

Maria Bzówka, Karolina Mitusińska, Agata Raczyńska, Tomasz Skalski, Aleksandra Samol, Weronika Bagrowska, Tomasz Magdziarz, Artur Góra

The paper studies tunnel evolution in soluble epoxide hydrolases, finding conserved tunnel-lining residues and variable residues that respond to evolutionary pressure, proposing methods for tunnel design and enzyme reengineering.

PLoS Computational Biology · May 17, 2022Peer-reviewedBioinformatics

Structural and Evolutionary Analysis Indicate that the SARS-CoV-2 Mpro is an Inconvenient Target for Small-Molecule Inhibitors Design

Maria Bzówka, Karolina Mitusińska, Agata Raczyńska, Aleksandra Samol, Jack A. Tuszyński, Artur Góra

The paper analyzes the structural and evolutionary features of SARS-CoV-2 Mpro, finding that its active site differences and flexibility make it a poor target for small-molecule inhibitors.

International Journal of Molecular Sciences · Apr 28, 2020Peer-reviewedMolecular Biology