Author

Chelsie Villanueva-Hayes

Hammersmith HospitalORCID 0009-0006-1132-7879Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Anissa Anindya WidjajaiD· 2 shared Ekhlas RahmaniD· 2 shared Ivan AndrewiD· 2 shared Katie O’Fee· 2 shared Konstantinos VanezisiD· 2 shared Mark D. SweeneyiD· 2 shared Michael LeeiD· 2 shared Paul J.R. BartoniD· 2 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Anissa Anindya WidjajaORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintSep 30, 2023

Interleukin 11 therapy causes acute heart failure and its use in patients should be reconsidered

Mark D. Sweeney, Katie O’Fee, Chelsie Villanueva-Hayes…·Stuart A. Cook

This paper identifies direct cardiomyocyte toxicities of IL11 therapy, showing it causes acute heart failure by activating JAK/STAT3, which questions its continued use in patients.

2 citations

mousebulk RNA-seq

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Molecular BiologyInternational Journal of Molecular SciencesPeer-reviewedAug 20, 2023

Cardiomyocyte-restricted expression of IL11 causes cardiac fibrosis, inflammation, and dysfunction.

Mark D. Sweeney, Katie O’Fee, Chelsie Villanueva-Hayes…·Stuart A. Cook

This study shows that IL11 expression in cardiomyocytes causes cardiac fibrosis, inflammation, and dysfunction, contradicting previous reports of its anti-fibrotic effects.

29 citationstop 3%

mousebulk RNA-seq

𝕏 PostBluesky