Author

Mark D. Sweeney

Hammersmith HospitalORCID 0000-0001-5098-0076Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Anissa Anindya WidjajaiD· 3 shared Stuart A. CookiD· 3 shared Wei‐Wen LimiD· 3 shared Chelsie Villanueva-HayesiD· 2 shared Ekhlas RahmaniD· 2 shared Ivan AndrewiD· 2 shared Katie O’Fee· 2 shared Konstantinos VanezisiD· 2 shared

Activity by Year

2023-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

Anissa Anindya WidjajaORCID

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Author profile →

4 papers

Recent·Most cited

Interleukin 11-induced microRNAs as functional mediators and circulating biomarkers of cardiac fibrosis

Roman Tikhomirov, Veronika Boichenko, Benedict Reilly-O’Donnell, Carla Lucarelli, Prashant Kumar Srivastava, Maryam Anwar, Chi Him Kendrick Yiu, Julia Dielesen, Victoria Maria Noakes, Santiago Nicolas Piella, Diana Kazharova, Mathilde Labbé, Zoe Kwan, Germana Zaccagnini, Catherine A. Mansfield, , Julia Gorelik

This study identifies miRNA-27b-5p and miRNA-497-5p as downstream effectors of IL-11-induced cardiac fibrosis and potential circulating biomarkers in aortic stenosis.

Circulation Research · Mar 17, 2026Peer-reviewedMolecular Biology

Interleukin 11 therapy causes acute heart failure and its use in patients should be reconsidered

Mark D. Sweeney, Katie O’Fee, Chelsie Villanueva-Hayes, Ekhlas Rahman, Michael Lee, Henrike Maatz, Eric L. Lindberg, Konstantinos Vanezis, Ivan Andrew, Emma R. Jennings, Wei‐Wen Lim, Anissa Anindya Widjaja, Norbert Hübner, Paul J.R. Barton, Stuart A. Cook

This paper identifies direct cardiomyocyte toxicities of IL11 therapy, showing it causes acute heart failure by activating JAK/STAT3, which questions its continued use in patients.

bioRxiv · Sep 30, 2023 · PreprintMolecular Biology

Cardiomyocyte-restricted expression of IL11 causes cardiac fibrosis, inflammation, and dysfunction.

Mark D. Sweeney, Katie O’Fee, Chelsie Villanueva-Hayes, Ekhlas Rahman, Michael Lee, Konstantinos Vanezis, Ivan Andrew, Wei‐Wen Lim, Anissa Anindya Widjaja, Paul J.R. Barton, Stuart A. Cook

This study shows that IL11 expression in cardiomyocytes causes cardiac fibrosis, inflammation, and dysfunction, contradicting previous reports of its anti-fibrotic effects.

International Journal of Molecular Sciences · Aug 20, 2023Peer-reviewedMolecular Biology

Inhibition of an immunometabolic axis of mTORC1 activation extends mammalian healthspan

Anissa Anindya Widjaja, Wei‐Wen Lim, Sivakumar Viswanathan, Sonia Pankaj Chothani, Ben Corden, Joyce Wei Ting Goh, Jessie Tan, Chee Jian Pua, Radiance Lim, Brijesh Kumar Singh, Dasan Mary Cibi, Susanne Weber, Sze Yun Lim, Eleonora Adami, Benjamin L. George, , Stuart A. Cook

This study shows that inhibiting IL11 improves healthspan in aged mice by reversing metabolic dysfunction, sarcopenia, and frailty.

bioRxiv · Jul 9, 2023 · PreprintMolecular Biology