Author

Katie O’Fee

Hammersmith HospitalPrimary ORCID profile (0009-0008-5322-8128 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Katie O’FeeiD2 papers · Institute of Cancer Research

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Anissa Anindya WidjajaiD· 2 shared Chelsie Villanueva-HayesiD· 2 shared Ekhlas RahmaniD· 2 shared Ivan AndrewiD· 2 shared Konstantinos VanezisiD· 2 shared Mark D. SweeneyiD· 2 shared Michael LeeiD· 2 shared Paul J.R. BartoniD· 2 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Anissa Anindya WidjajaORCID

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2 papers

Recent·Most cited

Interleukin 11 therapy causes acute heart failure and its use in patients should be reconsidered

Mark D. Sweeney, Katie O’Fee, Chelsie Villanueva-Hayes, Ekhlas Rahman, Michael Lee, Henrike Maatz, Eric L. Lindberg, Konstantinos Vanezis, Ivan Andrew, Emma R. Jennings, Wei‐Wen Lim, Anissa Anindya Widjaja, Norbert Hübner, Paul J.R. Barton, Stuart A. Cook

This paper identifies direct cardiomyocyte toxicities of IL11 therapy, showing it causes acute heart failure by activating JAK/STAT3, which questions its continued use in patients.

bioRxiv · Sep 30, 2023 · PreprintMolecular Biology

Cardiomyocyte-restricted expression of IL11 causes cardiac fibrosis, inflammation, and dysfunction.

Mark D. Sweeney, Katie O’Fee, Chelsie Villanueva-Hayes, Ekhlas Rahman, Michael Lee, Konstantinos Vanezis, Ivan Andrew, Wei‐Wen Lim, Anissa Anindya Widjaja, Paul J.R. Barton, Stuart A. Cook

This study shows that IL11 expression in cardiomyocytes causes cardiac fibrosis, inflammation, and dysfunction, contradicting previous reports of its anti-fibrotic effects.

International Journal of Molecular Sciences · Aug 20, 2023Peer-reviewedMolecular Biology