Structure-guided antisense-oligonucleotides selectively modulate frameshifting of a human gene
Ondřej Kostov, Myriam Moreno Swanton, Katie Waldon, Autumn M Matthews, Marija Ciba, Mathias Bogetoft Danielsen, Balázs Schäfer, Saheli Ganguly, Christopher C. Ebmeier, Marvin H. Caruthers, Alexandra M. Whiteley
This study identifies an antisense oligonucleotide that selectively modulates -1 ribosomal frameshifting of the PEG10 gene by targeting its RNA pseudoknot structure.
bioRxiv · Sep 7, 2026 · PreprintBiochemistry