Alexandra M. Whiteley

This study identifies an antisense oligonucleotide that selectively modulates -1 ribosomal frameshifting of the PEG10 gene by targeting its RNA pseudoknot structure.

This paper identifies PEG10 as a regulator of mRNA splicing in neurons, showing it mimics TDP-43 loss and affects NRG3 splicing in ALS patient samples.

This paper identifies UBQLN2 as a facilitator of PEG10 gag-pol degradation via UBE3A activity, revealing a stepwise mechanism involving UBQLN2 binding and ubiquitination.

This study shows that endogenous retrovirus-like proteins RTL8 and PEG10 regulate UBQLN2's recruitment to stress granules and alter their functional properties.