Marvin H. Caruthers

This study evaluates thiomorpholino antisense oligonucleotides (TMOs) as telomerase inhibitors, showing they reduce telomerase activity and limit cancer cell proliferation.

This study identifies an antisense oligonucleotide that selectively modulates -1 ribosomal frameshifting of the PEG10 gene by targeting its RNA pseudoknot structure.

The paper shows that inhibiting NMD in FSHD leads to widespread production of truncated RNA-binding proteins, some of which are toxic and can be detected in patient samples.