Tyler J. Kirby

This study shows that microtubule organization and detyrosination, not abundance, affect sarcomere shortening in skeletal muscle fibers.

This study shows that microtubule detyrosination in HCM causes nuclear shape changes and YAP1 signaling, which can be reversed by inhibiting detyrosination.

This study shows that culturing muscle fibers in a 3D hydrogel improves viability and preserves contractile function compared to 2D culture.