Coen A. C. Ottenheijm

The paper identifies MARPs as key modulators of titin-based mechanotransduction and shows mTORC1 regulates longitudinal muscle hypertrophy in response to stretch.

This study identifies an inflammatory myofiber state in ICU-acquired weakness linked to altered myosin dynamics through integrated single-fiber multi-omics analysis.

This study shows that culturing muscle fibers in a 3D hydrogel improves viability and preserves contractile function compared to 2D culture.

This study characterizes NEB mutations in NEM2 patients, revealing mechanisms of nebulin dysfunction and the potential therapeutic benefit of Omecamtiv mecarbil.