Author

Tom A. Hartl

BioMarin (United States)ORCID 0000-0002-0221-3427Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:Drosophila· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 1

Frequent Co-Authors

Ethan O. PerlsteiniD· 2 shared Joshua D. MastiD· 2 shared Tamy Portillo Rodriguez· 2 shared Andrew B. Berger· 1 shared Annemieke M Aartsma-RusiD· 1 shared Brett E. CrawfordiD· 1 shared Brian Heglar· 1 shared C. Tanganyika-de WinteriD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersNeuroscience

Ethan O. PerlsteinORCID

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Author profile →

3 papers

Recent·Most cited

Sequence determinants of efficient exon 44 skipping in Duchenne muscular dystrophy define design principles for steric-blocking antisense oligonucleotides

Enyang Han, Katherine Webster, Tiberiu Loredan Stan, C. Tanganyika-de Winter, Elizabeth M. van der Pijl, Jordan Tahquechi, Brian Heglar, Chad Koehler, Irinna Papangeli, Donnie Mackenzie, Brett E. Crawford, Annemieke M Aartsma-Rus, Tom A. Hartl

The paper identifies sequence and chemical features of ASOs that efficiently induce exon 44 skipping in DMD and defines design principles for therapeutic ASOs.

bioRxiv · Jul 1, 2026 · PreprintMolecular Biology

Glial control of sphingolipid levels sculpts diurnal remodeling of circadian circuits

John P. Vaughen, Emma K. Theisen, Irma Magaly Rivas‐Serna, Andrew B. Berger, Prateek R Kalakuntla, Ina Anreiter, Vera Christine Mazurak, Tamy Portillo Rodriguez, Joshua D. Mast, Tom A. Hartl, Ethan O. Perlstein, Richard J. Reimer, Michael Thomas Clandinin, Thomas R. Clandinin

This study shows that glial cells regulate sphingolipid levels to drive daily remodeling of circadian circuits in Drosophila.

Neuron · Aug 11, 2022Peer-reviewedNeuroscience

Defects in the neuroendocrine axis cause global development delay in aDrosophila model of NGLY1 Deficiency

Tamy Portillo Rodriguez, Joshua D. Mast, Tom A. Hartl, Tom Lee, Peter Sand, Ethan O. Perlstein

This study uses a Drosophila model of NGLY1 Deficiency to identify therapeutic compounds and gene modifiers that rescue developmental defects.

G3 Genes Genomes Genetics · May 7, 2018Peer-reviewedGenetics