Author

Irinna Papangeli

BioMarin (United States)ORCID 0000-0002-3151-4237Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Alessandro ArduiniiD· 1 shared Amelia Weber HalliD· 1 shared Amer-Denis AkkadiD· 1 shared Annemieke M Aartsma-RusiD· 1 shared Brett E. CrawfordiD· 1 shared Brian Heglar· 1 shared C. Tanganyika-de WinteriD· 1 shared Carolina RoselliiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperGenomics

Alessandro ArduiniORCID

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3 papers

Recent·Most cited

Sequence determinants of efficient exon 44 skipping in Duchenne muscular dystrophy define design principles for steric-blocking antisense oligonucleotides

Enyang Han, Katherine Webster, Tiberiu Loredan Stan, C. Tanganyika-de Winter, Elizabeth M. van der Pijl, Jordan Tahquechi, Brian Heglar, Chad Koehler, Irinna Papangeli, Donnie Mackenzie, Brett E. Crawford, Annemieke M Aartsma-Rus, Tom A. Hartl

The paper identifies sequence and chemical features of ASOs that efficiently induce exon 44 skipping in DMD and defines design principles for therapeutic ASOs.

bioRxiv · Jul 1, 2026 · PreprintMolecular Biology

Endothelial beta-arrestins Regulate Mechanotransduction by the Type II Bone Morphogenetic Protein Receptor in Primary Cilia

Saejeong Park, Zhiyuan Ma, Georgia Zarkada, Irinna Papangeli, Sarin N. Paluri, Nour Nazo, Xinyu Xiong, Félix E. Rivera-Molina, Derek K. Toomre, Sudarshan Rajagopal, Hyung J. Chun

This paper identifies beta-arrestins as key regulators of ciliary mechanotransduction in endothelial cells, showing their role in shear stress response and vascular development.

Pulmonary Circulation · Oct 1, 2022Peer-reviewedMolecular Biology

Transcriptional and Cellular Diversity of the Human Heart

Nathan R. Tucker, Mark D. Chaffin, Stephen J. Fleming, Amelia Weber Hall, Victoria A. Parsons, Kenneth C Bedi, Amer-Denis Akkad, Caroline N. Herndon, Alessandro Arduini, Irinna Papangeli, Carolina Roselli, François Aguet, Seung Hoan Choi, Kristin Ardlie, Mehrtash Babadi, , Patrick T. Ellinor

The paper uses single-nucleus RNA sequencing to define the transcriptional and cellular diversity of the non-failing human heart, identifying 9 major cell types and 20 subclusters.

Circulation · May 14, 2020Peer-reviewedGenomics