Tiberiu Loredan Stan

Four new Duchenne muscular dystrophy mouse models with clinically relevant exon deletions in the human DMD gene

The paper develops four humanized DMD mouse models with specific human exon deletions to test exon skipping therapies for Duchenne muscular dystrophy.

Sequence determinants of efficient exon 44 skipping in Duchenne muscular dystrophy define design principles for steric-blocking antisense oligonucleotides

The paper identifies sequence and chemical features of ASOs that efficiently induce exon 44 skipping in DMD and defines design principles for therapeutic ASOs.

Investigating the effects of prednisolone on behavior in mouse models of Duchenne muscular dystrophy

This study examines the effects of prednisolone on behavior in DMD mouse models, finding limited improvements in anxiety but no changes in social interaction or spatial learning.

The vitamin B3 analogue nicotinamide riboside has only very minor effects on reducing muscle damage in mdx mice

This study investigates the effects of nicotinamide riboside on muscle damage in mdx mice and finds no significant improvement in muscle pathology markers despite a slight increase in NAD+ levels in some models.