Pieter Sicco Hiemstra

This study shows that ageing reduces tissue-resident memory T cells in the upper airway, linked to impaired epithelial-immune crosstalk and reduced TGF-β signaling.

This paper presents an alveolus-on-chip model to study vascular-epithelial interactions and smoke-induced lung injury, showing that cigarette smoke disrupts vascular networks when exposed to alveolar epithelial cells.

This study shows cigarette smoke induces PPP1R15A through oxidative stress, which reduces pro-inflammatory cytokine production in bronchial epithelial cells.

The paper identifies a corticosteroid-sensitive gene cluster in COPD patients using asthma-derived transcriptomic signatures and links it to mast cell numbers and lung function improvement.