Author

Anna H.E. Roukens

Leiden UniversityORCID 0000-0002-1397-0992Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:flow cytometry· 2 Organism:human· 2 Approach:microscopy & imaging analysis· 1 Assay:proteomics· 1

Frequent Co-Authors

Alicia C. de Kroon· 2 shared Mirjam H.M. HeemskerkiD· 2 shared Simon P. JochemsiD· 2 shared Wesley HuismaniD· 2 shared Anne M. van der DoesiD· 1 shared Christiaan E.W. Smeenk· 1 shared Cilia R. PothastiD· 1 shared Dennis O. Mook‐KanamoriiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

Alicia C. de Kroon

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Ageing of the Upper Airway Epithelial Niche Limits Tissue-Resident T Cell Immunity

Wesley Huisman, Lisa A. King, Youvika Singh, Alicia C. de Kroon, Rosanne A. M. Steenbergen, Iris van der Valk, Renate S. Hagedoorn, Emile J. de Meijer, M. König, Tim Roek, Giovanni E. Loe-Sack-Sioe, Maurits T Wulffraat, Marjan J. T. van der Elst, Susan L. Kloet, Jutte J.C. de Vries, , Simon P. Jochems

This study shows that ageing reduces tissue-resident memory T cells in the upper airway, linked to impaired epithelial-immune crosstalk and reduced TGF-β signaling.

bioRxiv · Jul 16, 2026 · PreprintImmunology

Immuno-functionomics reveals geographical variation and a role for TLR8 in mRNA vaccine responses

Wesley Huisman, Shohreh Azimi, Thi Yen Nhi Nguyen, Alicia C. de Kroon, Karin de Ruiter, Dicky L. Tahapary, Mikhael D. Manurung, Cilia R. Pothast, Yvonne C. M. Kruize, Mirjam H.M. Heemskerk, Taniawati Supali, Leo G. Visser, Anna H.E. Roukens, Maria Yazdanbakhsh, Simon P. Jochems

The study uses spectral flow cytometry to analyze immune function across populations, revealing geographical differences and TLR8's role in mRNA vaccine responses.

iScience · Oct 25, 2025Peer-reviewedImmunology