Anne M. van der Does

This study shows that ageing reduces tissue-resident memory T cells in the upper airway, linked to impaired epithelial-immune crosstalk and reduced TGF-β signaling.

This paper presents an alveolus-on-chip model to study vascular-epithelial interactions and smoke-induced lung injury, showing that cigarette smoke disrupts vascular networks when exposed to alveolar epithelial cells.

This study shows LL-37 enhances pro-inflammatory oxylipins and chemokines via COX-2 and P2X7 receptor, while citrullinated LL-37 reduces these effects.

This study shows LL-37 and its citrullinated form suppress IL-17A/F-induced LCN-2 production in bronchial epithelial cells, reducing neutrophil migration and airway inflammation.

This study shows cigarette smoke induces PPP1R15A through oxidative stress, which reduces pro-inflammatory cytokine production in bronchial epithelial cells.

The paper compares mucociliary clearance in human and rat airways, finding species-specific structural differences that affect clearance effectiveness and identifying limitations of lab-grown cultures.