MicrobiologybioRxivPreprint
Microbial Scl1 Activates TGFBR1 receptor kinase signalling to Drive Fibrosis-Inflammation Axis in Alcohol-Associated Liver Disease
Manisha Yadav, Gaurav Tripathi, Anita Nandi…·Jaswinder Singh Maras
The paper identifies Streptococcal Scl1 as a bacterial protein that activates TGFβR1 signaling, driving fibrosis-inflammation in alcohol-associated liver disease through gut microbiota alterations.