Microbial Scl1 Activates TGFBR1 receptor kinase signalling to Drive Fibrosis-Inflammation Axis in Alcohol-Associated Liver Disease
Manisha Yadav, Gaurav Tripathi, Anita Nandi, Shabnam Shabnam, Jayesh Kumar Sevak, Vasundhra Bindal, Neha Sharma, Sanju Yadav, Vipul Sharma, Nupur Sharma, Babu Mathew, Yash Magar, Deepanshu Deepanshu, Sushmita Pandey, Rimsha Saif, , Jaswinder Singh Maras
The paper identifies Streptococcal Scl1 as a bacterial protein that activates TGFβR1 signaling, driving fibrosis-inflammation in alcohol-associated liver disease through gut microbiota alterations.
bioRxiv · Jul 8, 2025 · PreprintMicrobiology