Author

Samik Bose

Michigan State UniversityORCID 0000-0002-0273-9162Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:mechanistic / dynamical model· 2 Research Focus:protein folding & dynamics· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Benjamin J. OrlandoiD· 2 shared Alex DicksoniD· 1 shared Asmaa Aly· 1 shared Matthew W. Faber· 1 shared Melanie A. Orlando· 1 shared Tejas V. ShahiD· 1 shared Vardan T. KaramyaniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 12 mutual co-author links

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2 shared papersBiophysics

Benjamin J. OrlandoORCID

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2 papers

Recent·Most cited

Structure and conformational dynamics of the Pseudomonas CbrA transceptor

Melanie A. Orlando, Tejas V. Shah, Matthew W. Faber, Samik Bose, Benjamin J. Orlando

This paper determines the cryo-EM structure of CbrA, revealing its SLC5-STAC domains and how CbrX interacts with the transporter, providing insights into histidine transport and signaling mechanisms.

Protein Science · Aug 19, 2026Peer-reviewedBiophysics

Conformation Driven Enhancement of Neurolysin Activity in Presence of a Small Molecule Activator

Samik Bose, Asmaa Aly, Vardan T. Karamyan, Benjamin J. Orlando, Alex Dickson

This study identifies three binding sites of a small molecule activator on Neurolysin using MD simulations and Markov state modeling, revealing how these sites modulate conformational dynamics and catalytic activity.

bioRxiv · Jan 6, 2026 · PreprintBiophysics