Author

Antonio J. Pagán

MRC Laboratory of Molecular BiologyORCID 0000-0002-0280-1800Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:zebrafish· 1

Frequent Co-Authors

Bingnan LyuiD· 1 shared Elisabeth M. Busch‐NentwichiD· 1 shared Lalita RamakrishnaniD· 1 shared Michal Eisenberg‐BordiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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4 top collaborators · 6 mutual co-author links

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1 shared paperMicrobiology

Bingnan LyuORCID

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1 paper

Recent·Most cited

MicrobiologybioRxivPreprintFeb 7, 2026

Macrophage adaptation to hypoxia in the tuberculous granuloma potentiates mycobacterium-induced mitochondrial damage and granuloma necrosis

Antonio J. Pagán, Bingnan Lyu, Michal Eisenberg‐Bord…·Lalita Ramakrishnan

The paper shows that EsxA-induced mitochondrial damage in macrophages, combined with hypoxia-driven HIF-1 suppression of respiration, leads to granuloma necrosis and facilitates tuberculosis transmission.

DOI 10.64898/2026.02.06.702658

zebrafishexperimental assay

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