Lalita Ramakrishnan

The paper shows that EsxA-induced mitochondrial damage in macrophages, combined with hypoxia-driven HIF-1 suppression of respiration, leads to granuloma necrosis and facilitates tuberculosis transmission.

This study determines the cryo-EM structure of the MmpS5L5 efflux pump in Mycobacterium tuberculosis and identifies mutations that enhance bedaquiline efflux, suggesting new resistance mechanisms.

The paper develops an automated image processing tool to quantify bacterial burdens in zebrafish larvae by detecting their borders to distinguish internal from external bacteria.

The paper uses Bayesian analysis to show the LTA4H TT genotype improves survival in TBM patients in Vietnam and Indonesia, but only when disease severity is not the primary cause of mortality.

The paper was withdrawn due to fabricated data in experiments involving zebrafish.