Adrián Jacobo

This study shows that Vangl2 in different cell types of zebrafish neuromasts contributes to bidirectional hair-bundle polarity and tissue-wide alignment, with distinct roles in hair cells and support cells.

The paper shows Notch signaling drives asymmetry in zebrafish hair cells through a kinase-dependent mechanism, revealing a chiral bias in cell-pair rotations.

Ultrack improves cell tracking across 2D, 3D, and multi-channel time-lapse recordings by integrating multiple segmentations and temporal consistency, achieving state-of-the-art performance on benchmark datasets.

The paper uses optogenetic stimulation and calcium imaging in zebrafish to study how sensory inputs from neuromasts are processed in the brain, revealing nonlinear integration and sparse neuronal representations.

This study identifies Sema7A as a key regulator of neural circuit patterning in zebrafish lateral line by analyzing axonal arborization in wild-type and mutant models.

The paper develops robust virtual staining methods for cellular landmarks using deep learning, showing improved performance across cell types and imaging conditions.

The paper introduces a lipid-based transfection method for zebrafish embryos as an alternative to microinjection, improving efficiency and throughput for genetic studies.

Zebrafish embryos sequenced individually across ten developmental stages, paired with light-sheet lineage reconstruction, form an atlas and browser for in silico fate mapping.

The paper shows Notch1a-mediated lateral inhibition creates a bistable switch for opposite polarity in zebrafish hair cells, confirmed through theoretical and experimental approaches.

The paper maps the connectome of zebrafish neuromasts, revealing specific, redundant, and hierarchical wiring patterns, and identifies Notch signaling as mediating wiring specificity.