Author

Brooke A. Conti

Rockefeller UniversityORCID 0000-0002-0320-0732Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:DNA methylation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Agata SmogorzewskaiD· 2 shared Francis P. LachiD· 2 shared Benjamin R. SabariiD· 1 shared Cayla BrotoniD· 1 shared Chuong NguyeniD· 1 shared David J. ShieldsiD· 1 shared Deyan Tong· 1 shared Jason D. ArroyoiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersMolecular Biology

Agata SmogorzewskaORCID

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3 papers

Recent·Most cited

N6-methyladenosine in DNA promotes genome stability

Brooke A. Conti, Leo Novikov, Deyan Tong, Qing Xiang, Savon Vigil, Thomas J. McLellan, Chuong Nguyen, Nancy De La Cruz, Reshma T Veettil, Prashant Pradhan, Parag V. Sahasrabudhe, Jason D. Arroyo, Lei Shang, Benjamin R. Sabari, David J. Shields, Mariano Oppikofer

The paper identifies METTL3 and N6-methyladenosine (6mA) as factors promoting genome stability by repairing DNA base lesions.

eLife · Apr 7, 2025Peer-reviewedMolecular Biology

RTF2 controls replication repriming and ribonucleotide excision at the replisome

Brooke A. Conti, Penelope D. Ruiz, Cayla Broton, Nicolas J. Blobel, Molly C. Kottemann, Sunandini Sridhar, Francis P. Lach, Tom F. Wiley, Nanda Kumar Sasi, Thomas Carroll, Agata Smogorzewska

This study shows RTF2 regulates replication repriming and ribonucleotide excision at the replisome, ensuring efficient replication restart and preventing replication stress.

Nature Communications · Mar 2, 2024Peer-reviewedMolecular Biology

Suppression of non-homologous end joining does not rescue DNA repair defects in Fanconi anemia patient cells

Supawat Thongthip, Brooke A. Conti, Francis P. Lach, Agata Smogorzewska

This study shows that inhibiting NHEJ components does not rescue DNA repair defects in FA patient cells, with only partial suppression of chromosomal abnormalities by 53BP1 knockout.

Cell Cycle · Aug 30, 2020Peer-reviewedMolecular Biology