Yaniv Stein

TCF21 loss identifies a conserved inflammation-associated fibroblast state across Crohn's disease and ulcerative colitis

The paper identifies a conserved inflammation-associated fibroblast state in Crohn's disease and ulcerative colitis linked to TCF21 loss and shows TCF21 restoration can suppress inflammatory mediators.

Persistent stromal reprogramming defines incomplete mucosal healing and predicts therapeutic response in ulcerative colitis

The paper identifies persistent stromal reprogramming in mucosal healing of ulcerative colitis and links it to therapeutic response prediction.

The U-method: Leveraging expression probability for robust biological marker detection

The U-method identifies robust biological markers by comparing expression probabilities across clusters, showing consistent marker detection across cancer datasets and spatial transcriptomics.

A fibroblast-centric network drives cold fibrosis in the tumor microenvironment of lung squamous cell carcinoma

The paper identifies a cold fibrotic network in LUSC TME driven by CAFs and shows its conservation in other CIACs, suggesting therapeutic targets.