Merav Kedmi

The paper identifies persistent stromal reprogramming in mucosal healing of ulcerative colitis and links it to therapeutic response prediction.

This study uses spatial transcriptomics to map subcellular mRNA localization across tissues, revealing conserved and tissue-specific patterns.

Spatial transcriptomics of live healthy donor livers shows most hepatocyte genes are zonated, with key functions pericentrally shifted versus mouse, pig, boar and cow.

The paper identifies iridosomes as a subtype of lysosome-related organelles (LROs) in zebrafish, showing their role in guanine crystal formation through molecular and structural analysis.

The paper uses spatial transcriptomics to analyze thyroid heterogeneity, identifying a damage-response thyrocyte state that balances with hormone-producing states across scales.

This study uses spatial transcriptomics and proteomics to analyze IDH-mutant gliomas, revealing distinct spatial organization patterns across tumor grades.

This study uses spatial and single-cell transcriptomics to show that celiac disease alters enterocyte states by promoting aberrant zonal co-expression and metaplastic cells.

This study identifies and characterizes circulating endothelial cells (CECs) using single-cell data, revealing their diverse origins and plasticity, and links them to angiogenic programs in cancer.

This study investigates the molecular pathways in leucophores, revealing shared and distinct mechanisms with other pigment cells for crystal formation.

The paper characterizes age-related and inter-individual variation in circulating hematopoietic stem cells and establishes a normal reference to identify hematological disorders.

This paper develops a transgene-free human post-implantation embryo model from genetically unmodified naive PSCs, recapitulating key developmental stages and extra-embryonic tissues.

The paper introduces DestVI, a method for multi-resolution spatial transcriptomics analysis that captures continuous cell state variation, and applies it to study inflammation in lymph nodes and tumors.