Jack D. Rubien

This study uses AI to design protein fragments that regulate biomolecular condensates, showing success in multiple targets and revealing new interaction mechanisms.

Short UG-rich RNAs bind and stabilize TDP-43 RNA-recognition motifs to allosterically destabilize its prion-like domain helical region, preventing aggregation and mitigating neurodegeneration in cells and mice.

This paper introduces molecular time capsules to capture and preserve transcriptomic data from living cells, enabling retrospective analysis of gene expression during cellular transitions.

This study shows that TDP-43 represses a cryptic exon in UNC13A, and genetic variants associated with FTD/ALS increase cryptic exon inclusion when TDP-43 is dysfunctional.