Proteasomal regulation of ASK family kinases dictates cell fate under hyperosmotic stress
Xiangyu Zhou, Kengo Watanabe, Kazuhiro Morishita, Jun Hamazaki, Shigeo Murata, Isao Naguro, Hidenori Ichijo
This study shows that proteasome activity inactivates ASK3 by degrading ASK1, linking proteasome function to cell survival under hyperosmotic stress.
Journal of Biological Chemistry · Aug 6, 2025Peer-reviewedMolecular Biology