Author
Institute for Systems BiologyORCID 0000-0002-0348-1634Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Bretton Badenoch, Oliver Fiehn, Noa Rappaport, Pranjal Srivastava, Kengo Watanabe, Sriram Chandrasekaran, Richard A. Miller
The paper uses machine learning to identify plasma metabolomic and proteomic features that distinguish slow-aging mice from controls, finding triglycerides with varying fatty acid chain lengths as key predictors.
GeroScience · Dec 15, 2025Peer-reviewedBioinformatics
Xiangyu Zhou, Kengo Watanabe, Kazuhiro Morishita, Jun Hamazaki, Shigeo Murata, Isao Naguro, Hidenori Ichijo
This study shows that proteasome activity inactivates ASK3 by degrading ASK1, linking proteasome function to cell survival under hyperosmotic stress.
Journal of Biological Chemistry · Aug 6, 2025Peer-reviewedMolecular Biology
Dylan Ellis, Kengo Watanabe, Tomasz Maciej Wilmanski, Michael S. Lustgarten, Andres V Ardisson Korat, Gustavo Glusman, Jennifer Hadlock, Oliver Fiehn, Paola Sebastiani B, Nathan D. Price, Leroy Hood, Andrew T. Magis, Simon J. Evans, Lance T. Pflieger, Jennifer C. Lovejoy, , Noa Rappaport
The paper identifies APOE genotype-related metabolite associations with biological age and bioenergetics in humans, showing counterintuitive patterns in {varepsilon}2 and {varepsilon}4 carriers.
bioRxiv · Oct 17, 2024 · PreprintSystems Biology
Go Kasuya, Takanori Nakane, Takeshi Yokoyama, Yanyan Jia, Masato Inoue, Kengo Watanabe, Ryoki Nakamura, Tomohiro Nishizawa, Tsukasa Kusakizako, Akihisa Tsutsumi, Haruaki Yanagisawa, Naoshi Dohmae, Motoyuki Hattori, Hidenori Ichijo, Zhiqiang Yan, , Osamu Nureki
The paper presents the cryo-EM structure of the human LRRC8A protein, revealing its trimer-of-dimers assembly and structural features relevant to its function as a volume-regulated anion channel.
Nature Structural & Molecular Biology · Aug 17, 2018Peer-reviewedMolecular Biology