Cancer BiologybioRxivPreprint
Genotoxic chemotherapy impedes complement dependent cytotoxicity via Chk1-mediated CD59 regulation
Allison S. Y. Chan, Akshaya Anbuselvan, Patrick William Jaynes…·Anand Devaprasath D. Jeyasekharan
This study shows genotoxic chemotherapy increases CD59 expression, reducing complement-dependent cytotoxicity and rituximab efficacy in DLBCL via Chk1-mediated regulation.
DOI 10.1101/2025.02.17.638751