A lipid-laden macrophage niche drives immunosuppression in primary central nervous system lymphoma
Liang Hong, Subhashini Joshi, Min Liu…·Anand Devaprasath D. Jeyasekharan
This study identifies lipid-laden macrophages as an immunosuppressive niche in PCNSL, validated through spatial transcriptomics and mouse models, and shows SYK inhibition reverses their tumor-supportive activity.