Claudio Tripodo

This study uses a genetic anemia model to show that reduced thrombopoietin affects hematopoietic stem cells and the bone marrow niche through direct and indirect mechanisms.

This study shows that ENPP3 expression in HER2-positive breast cancer cells is linked to better prognosis by inhibiting epithelial-to-mesenchymal transition.

This study identifies lipid-laden macrophages as an immunosuppressive niche in PCNSL, validated through spatial transcriptomics and mouse models, and shows SYK inhibition reverses their tumor-supportive activity.

PatternExtract generates spatial point patterns from pathology images and cell coordinates using a two-kernel segmentation method and automated classification, validated on lymphoma data.

This paper shows that high-grade B cell lymphomas with MYC and BCL2 rearrangements originate from BCR-silenced follicular lymphoma cells that acquire IGL::MYC translocations, leading to resistance to CD79B-targeting therapy.

This study shows genotoxic chemotherapy increases CD59 expression, reducing complement-dependent cytotoxicity and rituximab efficacy in DLBCL via Chk1-mediated regulation.

This study identifies IRSp53's role in shaping the plasma membrane and controlling polarized transport during epithelial morphogenesis by regulating apical lumen formation and polarity determinants.