Soon Thye Lim

Germline genetic risk converges through intercellular crosstalk in tumor microenvironment

The paper integrates genetic and transcriptomic data to show that germline variants influence tumor microenvironment cell interactions and prognosis in nasopharyngeal carcinoma.

Large-Scale Whole-Exome Sequencing Association Study Implicates Genetic Effects on Viral Oncogenesis and Tumor Microenvironment in Nasopharyngeal Carcinoma

This study identifies three novel germline variants associated with nasopharyngeal carcinoma risk and introduces a refined polygenic risk score linked to EBV infection.

Correspondence: Recurrent GNAQ mutation encoding T96S in natural killer/T cell lymphoma

The paper identifies a recurrent GNAQ p.T96S mutation in NKTCL patients and suggests it may be a false-positive due to sequencing misalignment with the GNAQ pseudogene.

Recurrent PD-L1 Structural Rearrangements in Natural Killer/T Cell Lymphoma Patients with Complete Response to PD-1 Blockade Therapy

The paper identifies recurrent PD-L1 structural rearrangements and JAK3 mutations in NKTL patients achieving CR with PD-1 blockade therapy, suggesting genomic screening may improve patient selection.