Epithelial Plasticity and an Immune Suppressive Microenvironment Underpin Tumour Budding in Colorectal Cancer
Phimmada Hatthakarnkul, Natalie C. Fisher, Leonor Schubert Santana, Holly Leslie, Assya Legrini, Aula Ammar, Amna Matly, Kathryn A.F. Pennel, Ian R. Powley, Courtney Bull, Peter G. Alexander, Janos Sztanko, Jean A. Quinn, Jennifer R. Hay, Hannah Morgan, , Joanne Edwards
This study identifies TNF- and TGF-β signaling as drivers of tumour budding in CRC, linked to poor prognosis and an immunosuppressive microenvironment.
bioRxiv · Mar 5, 2025 · PreprintCancer Biology