Andrew D. Campbell

This study shows that poly(I:C) treatment in CMS4 colorectal tumors induces a pro-inflammatory, CMS1-like regenerative state and identifies biomarkers for predicting therapeutic response.

This study identifies SOX2 as a key driver of rapid tumorigenesis from a previously resistant skin cell population in mice, with implications for human cutaneous squamous cell carcinoma.

This study identifies TNF- and TGF-β signaling as drivers of tumour budding in CRC, linked to poor prognosis and an immunosuppressive microenvironment.

This study identifies a druggable PREX2/RAC1/PI3Kβ signalling axis in BRAF-mutant melanoma that confers resistance to therapies and can be targeted to improve treatment outcomes.

The paper identifies two neutrophil subtypes in cancer using single-cell RNA sequencing, showing their conservation across species and tumor types, and links them to immunosuppressive pathways.

MouSR is an open-source tool for rapid transcriptomic analysis of human or mouse data, enabling biological discovery without programming expertise.

The paper uses deep learning with t-SNE to analyze large datasets and overcome size limitations in bioinformatics.