Author

Natalie C. Fisher

Queen's University BelfastORCID 0000-0003-1769-7468Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:differential expression· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Approach:statistical model· 3 Assay:spatial transcriptomics· 2 Research Focus:batch correction / integration· 1 Research Focus:clustering· 1

Frequent Co-Authors

Philip D. DunneiD· 4 shared Courtney BulliD· 3 shared Sudhir B. MallaiD· 3 shared Aideen E. RyaniD· 2 shared Andrew D. CampbelliD· 2 shared Mark LawleriD· 2 shared Nigel Balfour JamiesoniD· 2 shared Raheleh AmirkhahiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersCancer Biology

Philip D. DunneORCID

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4 papers

Recent·Most cited

Cancer BiologyCommunications BiologyPeer-reviewedMay 26, 2026

Viral mimicry redirects immunosuppressed colorectal tumour landscapes towards a proinflammatory and CMS1-like regenerative state

Shania M. Corry, Svetlana S. Sakhnevych, Noha Ehssan Mohamed…·Philip D. Dunne

This study shows that poly(I:C) treatment in CMS4 colorectal tumors induces a pro-inflammatory, CMS1-like regenerative state and identifies biomarkers for predicting therapeutic response.

DOI 10.1038/s42003-026-10295-9

humanbulk RNA-seq

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Cancer BiologybioRxivPreprintMar 5, 2025

Epithelial Plasticity and an Immune Suppressive Microenvironment Underpin Tumour Budding in Colorectal Cancer

Phimmada Hatthakarnkul, Natalie C. Fisher, Leonor Schubert Santana…·Joanne Edwards

This study identifies TNF- and TGF-β signaling as drivers of tumour budding in CRC, linked to poor prognosis and an immunosuppressive microenvironment.

1 citation

humanbulk RNA-seq

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Cancer BiologyScientific ReportsPeer-reviewedDec 4, 2024

Evaluation of Gene Set Enrichment Analysis (GSEA) tools highlights the value of single sample approaches over pairwise for robust biological discovery.

Courtney Bull, Ryan M. Byrne, Natalie C. Fisher…·Sudhir B. Malla

This study compares GSEA tools and finds single sample approaches better capture biological distinctions than pairwise methods in cancer recurrence analysis.

14 citations

humanbulk RNA-seq

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Cancer BiologybioRxivPreprintJul 7, 2024

Library size can undermine accurate molecular and phenotypic subtyping in spatial transcriptomics data.

Natalie C. Fisher, Sudhir B. Malla, Nigel Balfour Jamieson, Philip D. Dunne

The paper identifies that reduced transcriptome panels in spatial transcriptomics can lead to inaccurate subtyping and phenotyping due to library size biases.

1 citation

spatial transcriptomicsstatistical model

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