Bo Wang

A Synthetic Archaeal Lipid Analog Enables Quantification of Substrate, Products, and Intermediates in the Tetraether Synthase Reaction

The paper introduces a synthetic lipid analog to quantify reaction intermediates and products in the Tetraether Synthase reaction, revealing a new GDGT-to-mAG ratio.

Structural and Spectroscopic Basis for Catalysis by a Class C Radical S-adenosylmethionine Methylase Involved in Nosiheptide/Nocathiacin Biosynthesis

This paper reports the structural and spectroscopic analysis of a class C radical SAM methylase involved in Nosiheptide biosynthesis, revealing key catalytic residues and radical mechanisms.

Evidence for an Organometallic Species Formed in the ArsL Reaction

The paper investigates how ArsL suppresses 5'-dA* formation and discovers an organometallic species involving ACP and the [Fe4S4] cluster to facilitate carbon-arsenic bond formation.

Structural Basis for Iterative Methylation by a Cobalamin-dependent Radical S-Adenosylmethionine Enzyme in Cystobactamids Biosynthesis

This paper reports X-ray crystal structures of a cobalamin-dependent radical S-adenosylmethionine enzyme, revealing how it facilitates iterative methylation of substrates and cobalamin.