Alexey Silakov

Redox Regulation in O2-Tolerant Hydrogenases: Insights from two homologues.

This study compares two [FeFe] hydrogenases, showing that TgHydA1 remains more stable under oxygen than CbHydA1 due to slower reactivation rates.

Promiscuous Metal Site in Hepatitis B Virus X Protein Binds anFe-S Cluster

This study identifies Fe-S cluster ligands in HBx, showing it binds both Fe-S and Zn, with implications for HBV replication and drug targeting.

Metal Coordination Dynamics Governs Selective Epoxidation in Hyoscyamine 6β-Hydroxylase: Integrated Experimental and Computational Insights

This paper investigates the catalytic mechanism of hyoscyamine 6β-hydroxylase, revealing that metal coordination dynamics govern selectivity between hydroxylation and epoxidation reactions.

Structural and Spectroscopic Basis for Catalysis by a Class C Radical S-adenosylmethionine Methylase Involved in Nosiheptide/Nocathiacin Biosynthesis

This paper reports the structural and spectroscopic analysis of a class C radical SAM methylase involved in Nosiheptide biosynthesis, revealing key catalytic residues and radical mechanisms.

Evidence for an Organometallic Species Formed in the ArsL Reaction

The paper investigates how ArsL suppresses 5'-dA* formation and discovers an organometallic species involving ACP and the [Fe4S4] cluster to facilitate carbon-arsenic bond formation.