Henri Leinonen

CoTRA provides an R/Shiny framework for bulk and single-cell RNA-seq analysis, offering integrated workflows and reproducibility across 49 criteria.

This paper designs tunable, rigid spike architectures on virus-like porous silica nanoparticles to enhance antigen delivery and immune response, showing improved vaccine efficacy compared to traditional adjuvants.

This study shows that Dyrk1a gene dosage affects bipolar cell development and retinal connectivity in mice.

This study shows female sex accelerates retinal degeneration in mouse models of retinitis pigmentosa, linked to increased lipid peroxidation after sexual maturity.

This paper generates a Cln8 p.R24G mouse model that phenocopies major clinical features of Northern epilepsy, including seizures and neurodegeneration.

This study investigates how spike structures on virus-like nanoparticles enhance immune responses in macrophages through proteomic analysis of signaling pathways.

ODDB integrates ocular disease gene-drug relationships to provide a comprehensive resource for molecular mechanisms and therapeutic opportunities.

This paper introduces biomimetic graphitic carbon nitride nanoparticles that enable multiscale photo-modulation of cells and tissues through light-responsive mechanisms.

The paper shows that homeostatic plasticity in the retina maintains sensitive night vision despite rod photoreceptor degeneration in a mouse model of Retinitis Pigmentosa.