Vesa‐Pekka Lehto

This study shows that biomimetic virus-like mesoporous silica nanoparticles activate NK cells through monocyte crosstalk by optimizing spike length, surface functionalization, and cell membrane coating.

This study shows virus-like nanospikes activate Piezo1 to enhance STING signaling in macrophages, promoting M1 polarization through mechanical and inflammatory signals.

This paper designs tunable, rigid spike architectures on virus-like porous silica nanoparticles to enhance antigen delivery and immune response, showing improved vaccine efficacy compared to traditional adjuvants.

This study develops hybrid lipid-VLPSi nanoparticles to enhance mRNA delivery, finding that amino-modified VLPSi significantly improves transfection efficiency compared to conventional LNPs.

This study identifies JQ1 and 45°C as optimal components for a combined chemo-photothermal therapy to induce immunogenic cell death in metastatic breast cancer.

This study investigates how spike structures on virus-like nanoparticles enhance immune responses in macrophages through proteomic analysis of signaling pathways.